Researchers identify the function of a protein that controls allergic diseases. Study could lead to development of medications for autoimmune disorders and other diseases, such as certain types of cancer
Researchers have demonstrated that influenza virus impairs the immune response to pneumococcus, especially monocyte activity. A software tool developed with FAPESP’s support was used to interpret the data.
By finding that the cancer drug also activates a key cellular receptor in the innate immune system, a study at the Center for Research in Inflammatory Diseases (CRID), in Brazil, may lead to new treatment strategies.
Study shows that the expression of PI3Kγ protein increases during infection by T. cruzi, an essential response in avoiding excessive inflammation and controlling parasitemia.
Researchers find that different types of inflammasomes – protein complexes responsible for initiating an inflammatory response in macrophages – can regulate each other to amplify signals of infection
Article published in The Journal of Neuroscience shows role of cytokine TNF in genesis of herpetic neuralgia. Discovery could lead to novel therapeutic approaches
In an article published in Nature Communications, researchers describe a cascade of events that unbalances the immune system, increasing the risk of recurring infections and death
Studies in mice suggest that two drugs capable of inhibiting the enzyme TrxR-1 – available commercially for other purposes – reduce inflammation and mortality in patients with sepsis