A study by RIDC CRID has discovered that when macrophages engulf cells infected by the novel coronavirus, they begin producing excessive amounts of pro-inflammatory molecules, and their capacity to recognize and phagocytize dead cells is reduced twelvefold.
In a study of the effects of cigarette smoking on exacerbation of the disease, scientists at RIDC CRID identified a novel pathway in the inflammatory process relating to bone damage.
In defense cells from patients hospitalized with the disease, researchers from RIDC CRID found signs of activation of a protein complex called the inflammasome, responsible for initiating the inflammatory response that can damage organs and lead to death. The findings could help identify drugs capable...
Analyses by researchers involved with RIDC CRID suggest alterations to pH caused by stomach acid lead to increase in expression of ACE2 and make cells more susceptible to infection by novel coronavirus.
Benefits were observed in a clinical trial involving 38 volunteers performed under the aegis of RIDC CRID. The drug is cheap and can shorten ICU stays but should not be used outside hospitals, the researchers warn.
A study conducted at the FAPESP-funded Center for Research on Inflammatory Diseases (CRID) will identify key processes triggered by SARS-CoV-2 in human cells.
In an article published in the Journal of Experimental Medicine, a group affiliated with a CRID reports that an enzyme associated with energy production in cells also participates in the differentiation of immune cells involved in exacerbated inflammation. The discovery could lead to more effective...
Researchers have correlated information on drugs, genes and diseases to identify potential candidates for psychiatric and neurological treatment. The methodology they developed will be used to search for drugs against COVID-19.