CEPID 2013-2024 


Principal Investigator:
Fernando de Queiroz Cunha

Education and Knowledge Diffusion Coordinator: 
Rita de Cassia Aleixo Tostes Passaglia
Technology Transfer Coordinator: João Santana da Silva

University of São Paulo (USP) 
Av. Bandeirantes, 3900
14049-900 - Ribeirão Preto, SP - Brasil
55 16 3315-3324

Center leaflet (pdf):

Center for Research on Inflammatory Diseases

Study presents novel therapeutic target for treatment of sepsis

Researchers affiliated with CRID showed that a protein called gasdermin D is involved in septic patients’ organ lesions. The study also proved that a drug originally indicated to treat alcohol dependence can inhibit the molecule’s action and prevent complications.

Researchers identify a novel cell type that makes survivors of sepsis more susceptible to infections

Many patients suffer from a significant decline in immunity lasting for years after they are discharged from hospital. In an article published in the journal Immunity, researchers at CRID reveal why this happens.

Study reveals arsenal used by parasite to inhibit cellular defense and aggravate leishmaniasis

Group affiliated with the Center for Research on Inflammatory Diseases showed that the parasite blocks the action of an enzyme using autophagy.

SARS-CoV-2 inhibits removal of dead cells by the immune system, favoring lung damage

A study by RIDC CRID has discovered that when macrophages engulf cells infected by the novel coronavirus, they begin producing excessive amounts of pro-inflammatory molecules, and their capacity to recognize and phagocytize dead cells is reduced twelvefold.

Researchers discover inflammatory mechanism responsible for bone erosion in rheumatoid arthritis

In a study of the effects of cigarette smoking on exacerbation of the disease, scientists at RIDC CRID identified a novel pathway in the inflammatory process relating to bone damage.

Study sheds light on immune mechanism that triggers cytokine storm typical of COVID-19

In defense cells from patients hospitalized with the disease, researchers from RIDC CRID found signs of activation of a protein complex called the inflammasome, responsible for initiating the inflammatory response that can damage organs and lead to death. The findings could help identify drugs capable...

Gastroesophageal reflux may increase risk of dying from COVID-19, study suggests

Analyses by researchers involved with RIDC CRID suggest alterations to pH caused by stomach acid lead to increase in expression of ACE2 and make cells more susceptible to infection by novel coronavirus.

Colchicine, an anti-inflammatory drug, accelerates recovery of hospitalized COVID-19 patients

Benefits were observed in a clinical trial involving 38 volunteers performed under the aegis of RIDC CRID. The drug is cheap and can shorten ICU stays but should not be used outside hospitals, the researchers warn.