Principal Investigator:
Mayana Zatz 
 
Education and Knowledge Diffusion Coordinator: Eliana Maria Beluzzo Dessen 
 
Technology Transfer Coordinator: Maria Rita dos Santos e Passos Bueno

HOST INSTITUTION
University of São Paulo (USP) 
Rua do Matão, 106 travessa 13
05508-090 - São Paulo, SP - Brasil
55 11 3091 7966 / 0878 
mayazatz@usp.br
genoma@ib.usp.br

ASSOCIATED INSTITUTIONS
Albert Einstein Hospital
Federal University of São Paulo (UNIFESP)
Fleury SA
Heart Institute (INCOR/USP)
Utrecht University
Zerbini Foundation

Center leaflet (pdf):

Human Genome and Stem-Cell Research Center

Men are the main transmitters of the novel coronavirus, study suggests

The hypothesis was raised by scientists at HUG-CELL, on the basis of an epidemiological survey involving 1,744 Brazilian couples where at least one partner was infected.

Cell-mediated immunity is essential to prevent reinfection by the novel coronavirus

HUG-CELL researchers studied the case of identical twins in which only one sibling was reinfected and developed complications after a second exposure to the virus. Their analysis showed that the adaptive immune response can be different even between individuals with the same genome.

Study maps immune system genes involved in resistance to SARS-CoV-2

A study at HUG-CELL analyzed genetic material from 86 couples in which only one spouse was infected. The results suggest that more frequent variants in the resistant spouses could lead to more efficient activation of natural killer (NK) cells, which are part of the innate immune system.

Researchers develop a technique to produce transplantable livers in the laboratory

A method created in Brazil by the Human Genome and Stem Cell Research Center could be used for large-scale production of livers for transplantation.

Brazilian researchers complete Latin America’s largest whole-genome sequencing of elderly people

Analysis of DNA from 1,171 over-sixties living in São Paulo will enable scientists to identify genetic mutations responsible for diseases or important to healthy aging, according to the authors, which are linked to HUG-CELL.

Study identifies group of genes with altered expression in autism

The dysregulation appeared to affect communication among neurons in the subjects of a study conducted at HUG-CELL. The discovery could improve diagnosis, which is currently based on the clinical analysis of symptoms.

Brazilian researchers develop saliva-based COVID-19 diagnostic test

Designed by the Human Genome and Stem Cell Research Center, the novel test may cost a quarter of those based on RT-PCR, considered the gold standard for diagnosis of the disease.

Study reveals genetic factors that can make placenta less capable of protecting fetus from zika

Findings reported by HUG-CELL researchers in PLOS Neglected Tropical Diseases help explain why only some babies whose mothers are infected during pregnancy are born with microcephaly and other anomalies.