The hypothesis was raised by scientists at HUG-CELL, on the basis of an epidemiological survey involving 1,744 Brazilian couples where at least one partner was infected.
HUG-CELL researchers studied the case of identical twins in which only one sibling was reinfected and developed complications after a second exposure to the virus. Their analysis showed that the adaptive immune response can be different even between individuals with the same genome.
A study at HUG-CELL analyzed genetic material from 86 couples in which only one spouse was infected. The results suggest that more frequent variants in the resistant spouses could lead to more efficient activation of natural killer (NK) cells, which are part of the innate immune system.
A method created in Brazil by the Human Genome and Stem Cell Research Center could be used for large-scale production of livers for transplantation.
Analysis of DNA from 1,171 over-sixties living in São Paulo will enable scientists to identify genetic mutations responsible for diseases or important to healthy aging, according to the authors, which are linked to HUG-CELL.
The dysregulation appeared to affect communication among neurons in the subjects of a study conducted at HUG-CELL. The discovery could improve diagnosis, which is currently based on the clinical analysis of symptoms.
Designed by the Human Genome and Stem Cell Research Center, the novel test may cost a quarter of those based on RT-PCR, considered the gold standard for diagnosis of the disease.
Findings reported by HUG-CELL researchers in PLOS Neglected Tropical Diseases help explain why only some babies whose mothers are infected during pregnancy are born with microcephaly and other anomalies.