Research at the cutting edge of knowledge

The São Paulo Research Foundation (FAPESP) supports Research, Innovation and Dissemination Centers (RIDCs) selected for funding for a period of up to eleven years. Each RIDC is expected to establish hub of excellent research in focus area, and must actively seek out and develop opportunities to have its research results contribute to high-impact applications, as well as contributing to education and dissemination of knowledge.

Study presents novel therapeutic target for treatment of sepsis

Researchers affiliated with CRID showed that a protein called gasdermin D is involved in septic patients’ organ lesions. The study also proved that a drug originally indicated to treat alcohol dependence can inhibit the molecule’s action and prevent complications.

Experimental treatment prevents Alzheimer's-associated weight gain in mice

In a study conducted at the Obesity and Comorbidities Research Center, a bile acid derivative known by the acronym TUDCA reduced food intake and increased energy expenditure in mice, improving quality of life. The results are promising for humans.

Treatment with injections of zika virus destroys brain tumors in mice without causing neurological damage

Experiments conducted at HUG-CELL showed that besides directly combating tumor cells, zika alerted the immune system to the presence of cancer. The study opens up prospects for the use of virotherapy for central nervous system tumors.

Researchers identify a novel cell type that makes survivors of sepsis more susceptible to infections

Many patients suffer from a significant decline in immunity lasting for years after they are discharged from hospital. In an article published in the journal Immunity, researchers at CRID reveal why this happens.

Men are the main transmitters of the novel coronavirus, study suggests

The hypothesis was raised by scientists at HUG-CELL, on the basis of an epidemiological survey involving 1,744 Brazilian couples where at least one partner was infected.

Only one in four Western Roman emperors died of natural causes

In a study of the underlying mathematical pattern associated with the reign of the Caesars, researchers at CeMEAI concluded that the chances of survival obeyed the 80/20 rule seen in many phenomena, from earthquake magnitudes to numbers of followers on social media.

Discovery facilitates search for drug to sabotage replication of SARS-CoV-2

Scientists at CIBFar investigated the mechanism that produces the main enzyme involved in the virus’s replication in cells. The findings are reported in the Journal of Molecular Biology

Innovative electron beam irradiation machine can create semiconductor materials

Designed and built by researchers at the Center for Development of Functional Materials, the device is much cheaper than the conventional technology.

A magneto-optical fiber to detect extremely weak magnetic fields

Brazilian scientists have developed an innovation that can be used in sensors to monitor brain function with even greater sensitivity than existing devices.