BV-FAPESP: research projects supported in this Center
OCRC in the Media: news about the Center
The Obesity and Comorbidities Research Center (OCRC) is one of the Research, Innovation and Dissemination Centers (RIDC) supported by FAPESP, and is active since June 2013.
OCRC coordinates scientific efforts to find solutions for obesity, a disease highly associated with a number of serious health problems such as type 2 diabetes, hypertension, atherosclerosis, and certain kinds of cancer. The overall mortality directly and indirectly associated with obesity is rapidly increasing in Brazil and all around the world – so much so that, today, it is considered a global epidemic.
The OCRC staff is constantly in contact with the industry and other potential users of the knowledge and products obtained through our research in order to speed up the transfer of knowledge to society.
In experiments with mice, researchers at the State University of Campinas observed alterations in feed consumption, weight gain, anxious behavior and an increase in central nervous system, adipose tissue and liver inflammation.
Brazilian researchers infected fat cells from subcutaneous and visceral tissue with SARS-CoV-2. Fat cells from organs in the abdominal cavity had a higher viral load and produced more pro-inflammatory molecules after contact with the virus.
Research by groups at the University of São Paulo and the State University of Campinas combined MRI scans of the brains of mild COVID-19 patients, analysis of brain tissue from people who died of the disease and experiments on human nerve cells infected in the laboratory.
Twenty-one patients with metabolic syndrome were given a calorie or protein restriction diet in a randomized clinical trial by Brazilian and Danish researchers. Weight loss, controlled blood pressure and improved blood sugar and lipid levels were observed in all participants.
In a study conducted at a FAPESP-funded research center, a bile acid derivative known by the acronym TUDCA reduced food intake and increased energy expenditure in mice, improving quality of life. The results are promising for humans.
In an article published in PLOS ONE, scientists at a FAPESP-supported research center describe the impact of hypoproteinemia on the expression of microRNAs associated with kidney development in rat embryos.
Researchers at the University of Campinas in Brazil reveal the mechanisms whereby SARS-CoV-2 disrupts the regulation of inflammation, coagulation and blood pressure when it infects alveolar cells, responsible for gas exchange in the lungs.
Led by research groups from the universities of Campinas and São Paulo, the investigation combined MRI scans of mild COVID-19 patients, analysis of brain tissue samples from patients who died from COVID-19, and experiments performed with human nerve cells infected in the laboratory.
Brazilian researchers are the only Latin American group to have had a project selected in an international request for applications by the Chan Zuckerberg Initiative. Funding of more USD 175,000 has been awarded to the study, which will be the first in Brazil to use single-cell analysis.