BV-FAPESP: research projects supported in this Center
CRID in the Media: news about the Center
The Center for Research in Inflammatory Diseases (CRID) was created with the aim of producing integrative and translational scientific research to identify and validate new biological pathways involved in the induction and resolution of inflammation. To this end, it counts on the experience of researchers from various fields of Biomedical Sciences linked to basic research (genetics, molecular and cell biology, immunology, pharmacology, and pathology) and clinical research (rheumatology, immunology, infectology, and dermatology), in addition to researchers in the area of bioinformatics.
Inflammatory diseases constitute a complex and heterogeneous group of diseases that affect more than 10% of the world population. The treatment alternatives currently available are limited and, in some cases, ineffective, considering that information on the underlying mechanisms of the inflammatory process and the pathophysiology of inflammatory diseases is still lacking.
The specific objective of the Center is to advance knowledge about inflammatory diseases (infectious, autoimmune, and related to the cardiovascular system) to recognize and understand the molecular, immunological, pathological, and pharmacological mechanisms involved; identify new biological targets for the development of pharmacological therapeutic tools; search for possible diagnostic markers and prognostic indications, and apply new knowledge to design and synthesize molecules aimed at treating inflammatory diseases.
2024-10-16
Through experiments in mice infected with a herpes virus, scientists identified an immune system sensor that recognizes viral fragments and activates neurons responsible for pain, independently of inflammation. The discovery paves the way for novel analgesic treatments.
2024-10-02
The synthetic peptide was inspired by ACE2, the protein to which the virus that causes COVID-19 binds to invade human cells. The results point to a route for the development of novel antivirals.
2024-09-04
In PLOS Pathogens, researchers at the University of São Paulo in Brazil report a study based on autopsies of 47 patients who died after being infected by the ancestral strain of SARS-CoV-2. The findings will support clinical decisions on the treatment of critical cases.
2024-08-28
Developed by a laboratory associated with the Center for Research in Inflammatory Diseases, “Conflitulus Lattes” – named after the Brazilian system of information on science and technology – helps avoid conflicts of interest in review panels.
2023-11-08
An article published in PNAS by Brazilian and Australian researchers describes a hitherto unknown protein with anti-oxidizing properties secreted by Coxiella burnetii, a Gram-negative intracellular bacterium, pointing to possible treatments for auto-immune diseases and even cancer.
2023-07-26
A team affiliated with a FAPESP-supported research center showed in mice that molecules capable of preventing the peptide C5a from binding to its cellular receptor helped prevent lung damage and other complications typical of severe COVID-19.
2023-07-19
A study conducted at the University of São Paulo and reported in PNAS explains hyperglycemia in hospitalized patients and shows how SARS-CoV-2 causes symptoms similar to those of diabetes.
2023-05-24
Leishmania alters the structure of the human protein that would normally induce the death of infected cells and weakens the inflammatory response. Reported in Nature Communications, the discovery could serve as a basis for better treatment.
2023-02-01
Scientists who analyzed the combined use of two drugs – paclitaxel and immune checkpoint inhibitors – made discoveries that could pave the way for future research to combat the pain caused by other diseases.
