CEPID 2013-2024 


Principal Investigator:
Fernando de Queiroz Cunha

Education and Knowledge Diffusion Coordinator: 
Rita de Cassia Aleixo Tostes Passaglia
Technology Transfer Coordinator: João Santana da Silva

University of São Paulo (USP) 
Av. Bandeirantes, 3900
14049-900 - Ribeirão Preto, SP - Brasil
55 16 3315-3324

Center leaflet (pdf):

Center for Research on Inflammatory Diseases

Pathway to resolve allergic asthma is discovered

Researchers identify the function of a protein that controls allergic diseases. Study could lead to development of medications for autoimmune disorders and other diseases, such as certain types of cancer

Study identifies a key cellular mechanism that triggers pneumonia in humans

Researchers have demonstrated that influenza virus impairs the immune response to pneumococcus, especially monocyte activity. A software tool developed with FAPESP’s support was used to interpret the data.

Chemotherapy drug paclitaxel also acts as an immune response modulator

By finding that the cancer drug also activates a key cellular receptor in the innate immune system, a study at the Center for Research in Inflammatory Diseases (CRID), in Brazil, may lead to new treatment strategies.

Study describes enzyme’s key role in immune response to Chagas disease parasite

Study shows that the expression of PI3Kγ protein increases during infection by T. cruzi, an essential response in avoiding excessive inflammation and controlling parasitemia.

Study helps understand how defense cells combat bacteria

Researchers find that different types of inflammasomes – protein complexes responsible for initiating an inflammatory response in macrophages – can regulate each other to amplify signals of infection

Study explains why patients with shingles feel pain

Article published in The Journal of Neuroscience shows role of cytokine TNF in genesis of herpetic neuralgia. Discovery could lead to novel therapeutic approaches

Study reveals mechanism that leads to immunosuppression after sepsis

In an article published in Nature Communications, researchers describe a cascade of events that unbalances the immune system, increasing the risk of recurring infections and death

Researchers describe novel strategy for combating sepsis

Studies in mice suggest that two drugs capable of inhibiting the enzyme TrxR-1 – available commercially for other purposes – reduce inflammation and mortality in patients with sepsis