SITE: http://redoxoma.iq.usp.br

Principal Investigator:
Ohara Augusto 
 
Education and Knowledge Diffusion Coordinator: Carmen Fernandez 
 
Technology Transfer Coordinator: Paolo Di Mascio

HOST INSTITUTION
University of São Paulo (USP)
Av. Prof. Lineu Prestes, 748
Cidade Universitária
05508-000 - São Paulo, SP - Brasil

ASSOCIATED INSTITUTIONS
Aarhus University, Denmark
AC Camargo Cancer Center
Atomic Energy and Alternative Energies Commission (CEA), France
Boston University, USA
Butantan Institute (IBu)
Centre National de la Recherche Scientifique (CNRS), France
Emory University, USA
Federal University of São Paulo (UNIFESP)
Harvard University, USA
Heart Institute (INCOR/USP)
Koç University, Turkey
Liverpool John Moores University, United Kingdom
National Institute on Aging (NIA), USA
São Paulo State University (UNESP)
University of Madrid, Spain
University of Milwaukee, USA
University of Rochester, USA

Center leaflet (pdf):

Center for Research on Redox Processes in Biomedicine

Enzyme may indicate predisposition to cardiovascular disease

Study suggests that people with low levels of PDIA1 in blood plasma may be at high risk of thrombosis; this group also investigated PDIA1’s specific interactions in cancer.

Biochemical compound responsible for blood pressure drop in sepsis is discovered

International research group demonstrates the involvement of singlet molecular oxygen in vasodilation, causing a sharp decline in blood pressure in severe inflammatory processes such as sepsis.

Diets consisting of fewer calories improve cell performance

Animal experiments have shown that caloric restriction causes cellular changes that can prevent diseases, the subject of a session at FAPESP Week London.

Scientists discover how light destroys cell membranes

Description of the mechanism could enhance the efficiency of photodynamic therapy, a medical treatment for cancer and bacterial infection, and permit the development of more efficient sunscreens.

Supplement enhances muscle detoxification in athletes

After taking beta-alanine for 28 days, volunteers eliminated more toxic substances from skeletal muscle following physical exercise. This discovery could help treat diseases caused by oxidative stress.

Novel activity of iron in all human cells is discovered

Labile iron prevents oxidation when it interacts with peroxynitrite, shows a study conducted at the Center for Research on Redox Processes in Biomedicine. The discovery has an impact on various biological processes.

Study helps understand functioning of anti-oxidant enzyme

Scientists at the Center for Research on Redox Processes in Biomedicine (Redoxome) show that an enzyme capable of ridding cells of an oxidizing substance can be found in different parts of the mitochondrion

Colored sunscreen protects skin from damage caused by visible light

Study performed at the Center for Research on Redox Processes in Biomedicine elucidates action mechanism of visible light on skin and questions typical use of sunscreen