SITE: http://redoxoma.iq.usp.br

Principal Investigator:
Ohara Augusto 
 
Education and Knowledge Diffusion Coordinator: Carmen Fernandez 
 
Technology Transfer Coordinator: Paolo Di Mascio

HOST INSTITUTION
University of São Paulo (USP)
Av. Prof. Lineu Prestes, 748
Cidade Universitária
05508-000 - São Paulo, SP - Brasil

ASSOCIATED INSTITUTIONS
Aarhus University, Denmark
AC Camargo Cancer Center
Atomic Energy and Alternative Energies Commission (CEA), France
Boston University, USA
Butantan Institute (IBu)
Centre National de la Recherche Scientifique (CNRS), France
Emory University, USA
Federal University of São Paulo (UNIFESP)
Harvard University, USA
Heart Institute (INCOR/USP)
Koç University, Turkey
Liverpool John Moores University, United Kingdom
National Institute on Aging (NIA), USA
São Paulo State University (UNESP)
University of Madrid, Spain
University of Milwaukee, USA
University of Rochester, USA

Center leaflet (pdf):

Center for Research on Redox Processes in Biomedicine

Study can help enhance the effectiveness of photodynamic therapy

A discovery by scientists affiliated with RIDC REDOXOME could contribute to the development of more powerful photosensitizers. When these molecules are exposed to light, they trigger biochemical processes that lead to the disruption of the cell membranes of tumors or pathogens.

Researchers discover a link between two important products of nitric oxide

Oxide plays a key role in cardiovascular and neurodegenerative diseases as well as cancer. Experiments conducted within the scope of RIDC REDOXOME reveal a hitherto unknown mechanism underlying the formation of nitroso thiols.

Enzyme may indicate predisposition to cardiovascular disease

Study suggests that people with low levels of PDIA1 in blood plasma may be at high risk of thrombosis; this group also investigated PDIA1’s specific interactions in cancer.

Biochemical compound responsible for blood pressure drop in sepsis is discovered

International research group demonstrates the involvement of singlet molecular oxygen in vasodilation, causing a sharp decline in blood pressure in severe inflammatory processes such as sepsis.

Diets consisting of fewer calories improve cell performance

Animal experiments have shown that caloric restriction causes cellular changes that can prevent diseases, the subject of a session at FAPESP Week London.

Scientists discover how light destroys cell membranes

Description of the mechanism could enhance the efficiency of photodynamic therapy, a medical treatment for cancer and bacterial infection, and permit the development of more efficient sunscreens.

Supplement enhances muscle detoxification in athletes

After taking beta-alanine for 28 days, volunteers eliminated more toxic substances from skeletal muscle following physical exercise. This discovery could help treat diseases caused by oxidative stress.

Novel activity of iron in all human cells is discovered

Labile iron prevents oxidation when it interacts with peroxynitrite, shows a study conducted at the Center for Research on Redox Processes in Biomedicine. The discovery has an impact on various biological processes.