Center leaflet (pdf):
In a study conducted at the Obesity and Comorbidities Research Center, a bile acid derivative known by the acronym TUDCA reduced food intake and increased energy expenditure in mice, improving quality of life. The results are promising for humans.
RIDC OCRC researchers reveal the mechanisms whereby SARS-CoV-2 disrupts the regulation of inflammation, coagulation and blood pressure when it infects alveolar cells, responsible for gas exchange in the lungs.
In an article published in PLOS ONE, scientists at RIDC OCRC describe the impact of hypoproteinemia on the expression of microRNAs associated with kidney development in rat embryos.
Higher blood glucose levels captured by defense cells provide energy for augmented viral replication, triggering overwhelming immune response that kills lung cells.
Scientists associated with the RIDC OCRC are the only Latin American group to have had a project selected in an international request for applications by the CZI. More than USD 175,000 has been awarded to the study, which will be the first in Brazil to use single-cell analysis.
Amongst all proposals the Scientific Board analyzed by March 31, two were selected, including a study at OCRC that evaluates the effectiveness of drugs that inhibit bradykinin against pulmonary inflammation in critical patients.
The blood test method makes use of machine learning and can be used to predict whether patients will put on weight, unless they change their habits. The project was conducted under the aegis of the Obesity and Comorbidities Research Center.
Experiments conducted under the aegis of the Obesity and Comorbidities Research Center showed that Zika virus inhibits tumor cell proliferation even when inactivated by high temperature.
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