Principal Investigator:
Ohara Augusto 
Education and Knowledge Diffusion Coordinator: Carmen Fernandez 
Technology Transfer Coordinator: Paolo Di Mascio

University of São Paulo (USP)
Av. Prof. Lineu Prestes, 748
Cidade Universitária
05508-000 - São Paulo, SP - Brasil

Aarhus University, Denmark
AC Camargo Cancer Center
Atomic Energy and Alternative Energies Commission (CEA), France
Boston University, USA
Butantan Institute (IBu)
Centre National de la Recherche Scientifique (CNRS), France
Emory University, USA
Federal University of São Paulo (UNIFESP)
Harvard University, USA
Heart Institute (INCOR/USP)
Koç University, Turkey
Liverpool John Moores University, United Kingdom
National Institute on Aging (NIA), USA
São Paulo State University (UNESP)
University of Madrid, Spain
University of Milwaukee, USA
University of Rochester, USA

Center leaflet (pdf):

Center for Research on Redox Processes in Biomedicine

Brazilian researchers discover how muscle regenerates after exercise

Adaptation of muscle tissue to aerobic exercise alters the metabolism of muscle stem cells, helping them recover from injury. Study at Redoxome may contribute to treatment of cachexia, sarcopenia and other conditions associated with lean mass loss.

Molecule that regulates muscle adaptation to exercise is discovered

An article in Cell by researchers from Harvard and from Redoxome/IQ-USP shows that the metabolite succinate is released by muscle cells during physical exercise and triggers a process of tissue remodeling that makes muscles stronger and enhances metabolic efficiency.

Study can help enhance the effectiveness of photodynamic therapy

A discovery by scientists affiliated with RIDC REDOXOME could contribute to the development of more powerful photosensitizers. When these molecules are exposed to light, they trigger biochemical processes that lead to the disruption of the cell membranes of tumors or pathogens.

Researchers discover a link between two important products of nitric oxide

Oxide plays a key role in cardiovascular and neurodegenerative diseases as well as cancer. Experiments conducted within the scope of RIDC REDOXOME reveal a hitherto unknown mechanism underlying the formation of nitroso thiols.

Enzyme may indicate predisposition to cardiovascular disease

Study suggests that people with low levels of PDIA1 in blood plasma may be at high risk of thrombosis; this group also investigated PDIA1’s specific interactions in cancer.

Biochemical compound responsible for blood pressure drop in sepsis is discovered

International research group demonstrates the involvement of singlet molecular oxygen in vasodilation, causing a sharp decline in blood pressure in severe inflammatory processes such as sepsis.

Diets consisting of fewer calories improve cell performance

Animal experiments have shown that caloric restriction causes cellular changes that can prevent diseases, the subject of a session at FAPESP Week London.

Scientists discover how light destroys cell membranes

Description of the mechanism could enhance the efficiency of photodynamic therapy, a medical treatment for cancer and bacterial infection, and permit the development of more efficient sunscreens.