Adaptation of muscle tissue to aerobic exercise alters the metabolism of muscle stem cells, helping them recover from injury. Study at Redoxome may contribute to treatment of cachexia, sarcopenia and other conditions associated with lean mass loss.
An article in Cell by researchers from Harvard and from Redoxome/IQ-USP shows that the metabolite succinate is released by muscle cells during physical exercise and triggers a process of tissue remodeling that makes muscles stronger and enhances metabolic efficiency.
A discovery by scientists affiliated with RIDC REDOXOME could contribute to the development of more powerful photosensitizers. When these molecules are exposed to light, they trigger biochemical processes that lead to the disruption of the cell membranes of tumors or pathogens.
Oxide plays a key role in cardiovascular and neurodegenerative diseases as well as cancer. Experiments conducted within the scope of RIDC REDOXOME reveal a hitherto unknown mechanism underlying the formation of nitroso thiols.
Study suggests that people with low levels of PDIA1 in blood plasma may be at high risk of thrombosis; this group also investigated PDIA1’s specific interactions in cancer.
International research group demonstrates the involvement of singlet molecular oxygen in vasodilation, causing a sharp decline in blood pressure in severe inflammatory processes such as sepsis.
Animal experiments have shown that caloric restriction causes cellular changes that can prevent diseases, the subject of a session at FAPESP Week London.
Description of the mechanism could enhance the efficiency of photodynamic therapy, a medical treatment for cancer and bacterial infection, and permit the development of more efficient sunscreens.