In defense cells from patients hospitalized with the disease, researchers from RIDC CRID found signs of activation of a protein complex called the inflammasome, responsible for initiating the inflammatory response that can damage organs and lead to death. The findings could help identify drugs capable of interrupting the process.
Roadmap proposes 25 research priorities in strategic areas to build a more equitable, resilient and sustainable future. RIDC CEM took part in constructing the document.
Project hosted by ITA addresses the effects of bulk viscosity in hypersonic simulations, particularly for Mars entry-type flows, and the capability to simulate hypersonic flows involving coupled radiative and convective heat transfer mechanisms.
Partnering with CNPEM, CIBFar researchers used the protein crystallography beamline to analyze more than 200 protein crystals from the novel coronavirus as they were exposed to tiny fragments of widely used drugs. If a compound fits perfectly into a target protein, its action can be blocked in the virus
The investigation involves BRAINN, CRID and OCRC RIDCs and combines MRI scans of mild COVID-19 patients, analysis of brain tissue samples from patients who died from COVID-19, and experiments performed with human nerve cells infected in the laboratory.
Adaptation of muscle tissue to aerobic exercise alters the metabolism of muscle stem cells, helping them recover from injury. Study at Redoxome may contribute to treatment of cachexia, sarcopenia and other conditions associated with lean mass loss.
The NeuroMat study featuring collaboration of South African researchers is the first to prove, using a graph analysis tool, that REM dream narratives tend to be more complex and connected than reports of non-REM dreams.
Monoclonal antibody tested by RIDC CTC researchers and experimental drug given to patients in Italy by University of Pennsylvania research group promoted rapid improvement of respiratory function in patients hospitalized in severe condition.
An article in Cell by researchers from Harvard and from Redoxome/IQ-USP shows that the metabolite succinate is released by muscle cells during physical exercise and triggers a process of tissue remodeling that makes muscles stronger and enhances metabolic efficiency.
Opportunity at RIDC BRAINN is aimed at candidates with strong interest in genomics and integrative analytical approaches for -omics data.