Center for Research on Inflammatory Diseases
Brazilian researchers have developed an algorithm to identify the protozoan Trypanosoma cruzi in photographs of blood samples taken with a mobile phone camera. The low-cost method is described in the journal PeerJ and can be reproduced.
Center for Cell-Based Therapy
Research that can increase Brazil’s access to CAR T-cell therapy, an increasingly important strategy for treating cancer, is under way at the University of São Paulo’s Center for Cell-Based Therapy (CTC) in Ribeirão Preto, and the Butantan Institute.
Center for Research and Innovation in Biodiversity and Drug Discovery
Advanced drug discovery methods have led to advances in the search for treatments for some neglected tropical diseases, including leishmaniasis and Chagas, but research on schistosomiasis and other diseases caused by worms remains at an early stage, according to an article in Drug Discovery Today by Brazilian researchers.
Human Genome and Stem-Cell Research Center
Universities, research institutions and agencies of the São Paulo State Government will join forces in 15 new centers announced during a ceremony held to celebrate FAPESP’s 60th anniversary. The centers will address problems in areas ranging from human and animal health to the energy transition and climate change.
Center for Research in Mathematical Sciences Applied to Industry
Mathematic simulations showed that well-executed non-pharmacological measures reduce the spread of COVID-19 even in places with low vaccination coverage. According to the authors, however, up to 80% of the population could catch the disease if preventive protocols are abandoned.
Optics and Photonics Research Center
Devices that combine laser irradiation, ultrasound and suction help regenerate tissue and treat muscle, joint, skin, neurological and lung damage. Protocols created via business-university partnerships are being tested and can be applied by treatment centers across Brazil.
Center for Research on Inflammatory Diseases
The discovery is reported by researchers at Harvard University and the University of São Paulo in Nature Neuroscience, and could serve as a basis for the development of treatments for different diseases.
Center for Research and Development of Functional Materials
The material is not an active ingredient but an adjuvant, and was successfully tested on an influenza virus in research conducted by an international team of scientists with Brazilian participation and reported in an article in Nature.
Food Research Center
This was the main finding of a study by scientists affiliated with a FAPESP-supported research center. The effect may be associated with a mechanism whereby the fruit increases expression of an insulin-related microRNA.
Brazilian Research Institute for Neuroscience and Neurotechnology
Scientists at a FAPESP-funded research center reprogrammed skin cells from patients with epilepsy to differentiate into cortical organoids with hallmarks of the malformation known as focal cortical dysplasia.
Center for Research on Redox Processes in Biomedicine
First-ever study to show correlation between inhibition of protein HSP70 and dysfunction of cells in inner lining of blood vessels, one of the factors involved in chronic thromboembolic pulmonary hypertension.
Center for Research and Development of Functional Materials
Designed for use as food packaging, the material is produced by scientists at São Paulo State University from gelatin, clay and a nanoemulsion of black pepper essential oil.
Center for Cell-Based Therapy
Patients submitted to a procedure that “resets” the immune system were tracked for a year by scientists at a FAPESP-supported research center. Their clinical improvement correlated with renewal of a group of defense cells known as B lymphocytes.
Center for Research on Inflammatory Diseases
In a study conducted by researchers at the University of São Paulo involving experiments on mice, the synthetic substance not only prevented the neuropathic pain typically induced by chemo drugs but was also beneficial against cancer.
Center for Research in Mathematical Sciences Applied to Industry
Using two low-cost techniques, researchers in Brazil differentiate patients with the disease from healthy subjects. Next steps include refining the approach to diagnose the disease in its early stages.
Center for Research on Inflammatory Diseases
Researchers affiliated with a FAPESP-funded research center showed that a protein called gasdermin D is involved in septic patients’ organ lesions. The study also proved that a drug originally indicated to treat alcohol dependence can inhibit the molecule’s action and prevent complications.
Human Genome and Stem-Cell Research Center
Experiments conducted at a FAPESP-supported research center showed that besides directly combating tumor cells, zika alerted the immune system to the presence of cancer. The study opens up prospects for the use of virotherapy for central nervous system tumors.
Obesity and Comorbidities Research Center
In a study conducted at a FAPESP-funded research center, a bile acid derivative known by the acronym TUDCA reduced food intake and increased energy expenditure in mice, improving quality of life. The results are promising for humans.
Center for Research and Innovation in Biodiversity and Drug Discovery
The point was stressed by participants in the 6th FAPESP 60 Years Conference, featuring experts from Brazil, the UK and the US who discussed the search for drugs to treat diseases that affect some 2 billion people worldwide.
Center for Research in Mathematical Sciences Applied to Industry
In a study of the underlying mathematical pattern associated with the reign of the Caesars, researchers at a FAPESP-supported center concluded that the chances of survival obeyed the 80/20 rule seen in many phenomena, from earthquake magnitudes to numbers of followers on social media.
