Center for Research on Inflammatory Diseases
A study conducted at the University of São Paulo and reported in PNAS explains hyperglycemia in hospitalized patients and shows how SARS-CoV-2 causes symptoms similar to those of diabetes.
Center for Research on Redox Processes in Biomedicine
Researchers at the University of São Paulo observed the effects of adiponectin in trials involving blood samples from lean and obese subjects. The discovery points to novel routes to treatment for type 2 diabetes and related dysfunctions.
Antimicrobial Resistance Institute of São Paulo (Aries Project)
A study conducted at the Federal University of São Paulo shows that 20% of patients with bloodstream infections are not treated, and at least half of those treated die. Diagnostic techniques must improve, the authors warn.
Brazilian Research Institute for Neuroscience and Neurotechnology
Brazilian researchers analyzed data from MRI scans and various tests to detect biological alterations linked to the neurological symptoms most reported by patients, especially anxiety, depression, sleepiness and fatigue. The latest results were presented to the ninth edition of BRAINN Congress.
Center for Research, Teaching, and Innovation in Glass
The technique was developed at the Federal University of São Carlos (UFSCar) in São Paulo state, Brazil, and could impact the manufacturing of batteries, smartphone screens and other devices.
Center for Research on Toxins, Immune-Response and Cell Signaling
A research group at Butantan Institute performed tests on animal models with asthma as a reference and demonstrated that the peptide from Thalassophryne nattereri, common in North and Northeast Brazil, is safe and efficacious.
Center for Research on Inflammatory Diseases
Leishmania alters the structure of the human protein that would normally induce the death of infected cells and weakens the inflammatory response. Reported in Nature Communications, the discovery could serve as a basis for better treatment.
Center for Research and Innovation in Biodiversity and Drug Discovery
In vitro experiments were conducted at a FAPESP-supported research center with a synthetic peptide inspired by molecules secreted by the probiotic bacterium Lactobacillus plantarum.
Food Research Center
Scientists at a FAPESP-supported research center combined substances extracted from fruit residues and egg white to package nanoparticles of anthocyanin, a plant pigment with antioxidant action. This nanoencapsulation prevents breakdown of the molecule and lets a larger amount reach the gut, where it is absorbed.
Center for Research and Development of Functional Materials
The novel material was synthesized at the Center for Development of Functional Materials. The aim of the study was to combat the contamination caused by inappropriate disposal of pesticides and pharmaceuticals.
Center for Research on Inflammatory Diseases
Scientists who analyzed the combined use of two drugs – paclitaxel and immune checkpoint inhibitors – made discoveries that could pave the way for future research to combat the pain caused by other diseases.
Center for Research and Development of Functional Materials
A company funded by FAPESP’s program to support innovation by small businesses is launching a dietary supplement for consumer hair care.
Center for Computational Engineering and Sciences
A study conducted at the State University of Campinas integrated knowledge in several fields with high-performance computing to investigate the properties of water inferred to exist in large quantities deep inside the ice giants.
Center for Research on Inflammatory Diseases
Neuropathic pain is chronic and caused by injury to the nervous system, affecting between 3% and 15% of the population. The only treatment options currently available are drugs originally developed for other conditions, such as epilepsy or depression.
Center for Cell-Based Therapy
The dynamics of SARS-CoV-2 variant substitution in the town where a clinical trial of vaccination effectiveness was conducted matched the pattern seen elsewhere in the country, but most cases were mild. The researchers analyzed 4,375 whole genomes of the virus.
Obesity and Comorbidities Research Center
Brazilian researchers infected fat cells from subcutaneous and visceral tissue with SARS-CoV-2. Fat cells from organs in the abdominal cavity had a higher viral load and produced more pro-inflammatory molecules after contact with the virus.
Human Genome and Stem-Cell Research Center
The importance of organizing and assuring access to the government’s healthcare data via the SUS was highlighted in a presentation by Ester Sabino, a professor at the University of São Paulo, to a webinar hosted by the São Paulo State Academy of Sciences. Data integration and access would benefit researchers and the Health Ministry, and help to direct investment in the sector.
Center for Research on Inflammatory Diseases
A study conducted at the University of São Paulo shows that flaws in the metabolization of ATP, one of the main sources of cellular energy, can lead to dysregulation of the immune system and a dangerously exacerbated inflammatory response to infection by the novel coronavirus.
