Obesity and Comorbidities Research Center
In tests with rodents, researchers observed that the immune system attempts to mitigate damage to the hypothalamus caused by food, which can lead to obesity in the long term. Animals whose migration of these cells was inhibited experienced greater weight gain, increased fat accumulation, and worsened metabolic markers.
Center for Research on Biodiversity Dynamics and Climate Change
Workshop held at the State University of Campinas as part of the Research Program on Global Climate Change outlines the challenges to be faced and the scientific efforts to predict and mitigate the problems caused by global warming.
Cancer Theranostics Innovation Center
The new functionalities allow the Cancer Theranostics Innovation Center to generate dynamic, more detailed images and provide more accurate diagnoses. The device is available to the scientific community in the state of São Paulo.
Center for Research in Mathematical Sciences Applied to Industry
Simple quantum-classical neural networks achieve good results in classifying lesions with fewer computational parameters. Scientists from São Paulo State University demonstrated a hybrid model at an international symposium.
Center for Research on Biodiversity Dynamics and Climate Change
Meeting at the State University of Campinas with a new generation of researchers points to collaboration between sectors to mitigate the consequences of global warming with climate justice.
Research, Innovation and Dissemination Center in Governance of Global Environmental Changes (FGVearth)
FAPESP’s new Research, Innovation, and Dissemination Center is launched two months before COP30 and is expected to become an international reference for innovative solutions to environmental challenges.
Antimicrobial Resistance Institute of São Paulo (Aries Project)
A vulture recently arrived at the Santos Municipal Orchid Garden and an owl living in captivity for ten years were colonized by antibiotic-resistant Escherichia coli.
Center for Carbon Research in Tropical Agriculture
These minerals stabilize soil organic carbon, preventing the release of greenhouse gases. However, these ecosystems, known as “blue carbon forests,” have suffered degradation due to changes in land use.
Center for Research on Redox Processes in Biomedicine
International team of researchers discovered that high levels of an enzyme called PRDX6 are associated with a subtype of neuroblastoma; animal studies showed that inhibiting the molecule caused a reduction in tumors.
Center for Carbon Research in Tropical Agriculture
Countries such as Colombia and Venezuela lead the way in terms of the extent of healthy soils, while regions such as the Brazilian Northeast, northern Mexico and parts of Chile and Argentina face the greatest challenges. The data can guide public policies for conservation.
Center for Research on Redox Processes in Biomedicine
Global guideline establishes new standard for investigating bioactive lipids related to inflammation, immunity, cancer, and neurodegenerative and cardiovascular diseases. Accurately quantifying them in biological samples is challenging and requires rigorous methodologies.
Optics and Photonics Research Center
Researchers at a FAPESP-supported research center have managed to reduce Candida albicans’ resistance to fungicides by incorporating photodynamic inactivation techniques into the treatment. The results of the study indicate that the technology can be used in both human healthcare and the prevention of food contamination.
Brazilian Research Institute for Neuroscience and Neurotechnology
Publicly available algorithm facilitates lesion identification and surgical planning for patients with focal cortical dysplasia, a malformation associated with a drug-refractory form of the disease.
Center for Research on Biodiversity Dynamics and Climate Change
International team of researchers issues global warning about the need to include frugivores in conservation, forest restoration, and climate change mitigation strategies.
Human Genome and Stem-Cell Research Center
Organoids were developed from the blood cells of centenarians who are part of a project conducted at the Human Genome and Stem Cell Research Center to discover genes that protect the brain from the effects of aging.
Center for Research and Innovation in Biodiversity and Drug Discovery
In pre-clinical tests conducted at the University of São Paulo, compounds called batzelladins were effective even against strains of Plasmodium that are resistant to conventional antimalarial drugs.
Center for Research on Biodiversity Dynamics and Climate Change
Acetic acid, a component of vinegar, was used by researchers in the state of São Paulo to fractionate kraft lignin. The method produces nanoparticles with different properties, including UV protection.
Antimicrobial Resistance Institute of São Paulo (Aries Project)
FAPESP will begin supporting the Latin American Center for Medical Mycology, a global network of laboratories led by the University of Exeter in the United Kingdom, which also has a unit in South Africa and will soon open another in Asia. Over five years, the foundation will contribute approximately £ 750,000, while the British institution will invest an additional £ 1 million.
Obesity and Comorbidities Research Center
In tests with rodents, researchers from the State University of Campinas and their collaborators found that hyperactivation of the PARP1 protein after exhaustive training was associated with decreased performance, fatigue, and behavioral symptoms of overtraining. Animals treated with a drug that inhibits the molecule’s activity did not exhibit the condition.
Center for Research on Redox Processes in Biomedicine
A yeast experiment conducted at a FAPESP-supported research center shows how deficiencies in the proteasome, which is responsible for eliminating damaged and non-functional proteins, affect the metabolism of mitochondria, the organelles that generate energy for cells.
